2010•Epidemiology and Infectious DiseasesOpen access
TLR-2 and TLR-4 expression levels as a prognostic index for recovery from chlamydiasis
Stanislav Stepanovich Bayrakova, E A Voropaeva, В. А. Алешкин, S S Afanas'ev, A V Karaulov, L I Kafarskaya, Yu V Nesvizhskiy, Б. А. Ефимов, A.N. Shkoporov, O G Grechishnikova, С А Леваков, V A Metel'skaya, М. С. Афанасьев, Е. А. Егорова, V V Slobodenyuk, E V Fandeev, А Л Байракова, Ye A Voropayeva, V. A. Alyoshkin, Stanislav Afanasyev, A V Karaulov, L I Kafarskaya, Yu. V. Nesvizhsky, B A Yefimov, A N Shkoporov, O G Grechishnikova, С А Леваков, V. A. Metelskaya, M. S. Afanasyev, Ye. A. Yegorova, V V Slobodenyuk, Ye V Fandeyev
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Abstract
The authors studied an association between the expression of TLR-2 and TLR-4 on the epithelial surfaces of the urogenital tract and the clinical manifestations of female urogenital chlamydial infection. Clinical and laboratory studies were conducted in 41 patients with acute urogenital chlamydial infection, 29 patients with chronic urogenital chlamydial infection, 30 patients with a history of diagnosed urogenital chlamydiasis (the markers of these microorganisms had not been detected in the urogenital tract by any of the used studies for a year), and 32 healthy female donors (a control group). The levels of TLR-2 and TLR-4 can serve as criteria for evaluating the degree of chlamydial infection and the presence of an inflammatory process in patients. The eradication of the pathogen can be judged from the changes in the levels of TLR-2 and TLR-4 in some cases when the causative agent was not identified by laboratory tests before treatment and the diagnosis was established in a patient from the markers that were indirectly indicative of her chlamydial infection. The enhanced protective reaction in the focus of affliction is always accompanied by increased TLR-2 and TLR-4 activation. The low levels of TLR-2 and TLR-4 can indicate that the infectious process may become chronic.