2021•International Journal of Molecular SciencesOpen access

Acupuncture Modulates Intracranial Self-Stimulation of the Medial Forebrain Bundle in Rats

Seong Shoon Yoon, Jaesuk Yun, Bong Hyo Lee, Hee Young Kim, Chae Ha Yang

Abstract

Acupuncture affects the central nervous system via the regulation of neurotransmitter transmission. We previously showed that Shemen (HT7) acupoint stimulation decreased cocaine-induced dopamine release in the nucleus accumbens. Here, we used the intracranial self-stimulation (ICSS) paradigm to evaluate whether HT stimulation regulates the brain reward function of rats. We found that HT stimulation triggered a rightward shift of the frequency-rate curve and elevated the ICSS thresholds. However, HT7 stimulation did not affect the threshold-lowering effects produced by cocaine. These results indicate that HT7 points only effectively regulates the ICSS thresholds of the medial forebrain bundle in drug-naïve rats.

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Key concepts: Medial forebrain bundle, Brain stimulation reward, Stimulation, Nucleus accumbens, Dopamine, Neuroscience, Forebrain, Neurotransmitter