ScholarLens Back to search
2021•Advances in biological sciences research/Advances in Biological Sciences ResearchOpen access

The Circulating Level of IL-1β in Patients with Age-related Macular Degeneration (AMD) in Yogyakarta: Characteristics to Disease Activity

Supanji Supanji, Ayudha Bahana Ilham Perdamaian, Anindita Dianratri, Muhammad Eko Prayogo, Muhammad Bayu Sasongko, Firman Setya Wardhana, Tri Wahyu Widayanti, Angela Nurini Agni, Chio Oka

Open full text 0 citations

Abstract

Age-related Macular Degeneration (AMD) is leading factors for blindness and impaired visual acuity in developed countries.It is importance to study the dynamic of cytokines concentration during the exudative event of AMD to contribute in the future drugs inventions.This research aims to investigate the IL-1β profiles in plasma of exudative AMD patients.In this cross-sectional study, blood plasma samples from 17 AMD patients and 23 age-matched were collected.Samples were examined for IL-1β inflammatory cytokines using a commercially available ELISA.Acquired data were log transformed to normalize the outlier prior student T-test (SPSS software).Based on recent research, there is a statistically difference of IL-1β among AMD patients and control.IL-1 β concentration were higher at control.Detection of high level of inflammatory cytokines supports a role for inflammation in AMD pathogenesis.

Open-access reader

About this research paper

What this paper is about

Age-related Macular Degeneration (AMD) is leading factors for blindness and impaired visual acuity in developed countries.It is importance to study the dynamic of cytokines concentration during the exudative event of AMD to contribute in the future drugs inventions.This research aims to investigate the IL-1β profiles in plasma of exudative AMD patients.In this cross-sectional study, blood plasma samples from 17 AMD patients and 23 age-matched were collected.Samples were examined for IL-1β inflammatory cytokines using a commercially available ELISA.Acquired data were log transformed to normalize the outlier prior student T-test (SPSS software).Based on recent research, there is a statistically difference of IL-1β among AMD patients and control.IL-1 β concentration were higher at control.Detection of high level of inflammatory cytokines supports a role for inflammation in AMD pathogenesis.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Age-related Macular Degeneration (AMD) is leading factors for blindness and impaired visual acuity in developed countries.It is importance to study the dynamic of cytokines concentration during the exudative event of AMD to contribute in the future drugs inventions.This research aims to investigate the IL-1β profiles in plasma of exudative AMD patients.In this cross-sectional study, blood plasma samples from 17 AMD patients and 23 age-matched were collected.Samples were examined for IL-1β inflammatory cytokines using a commercially available ELISA.Acquired data were log transformed to normalize the outlier prior student T-test (SPSS software).Based on recent research, there is a statistically difference of IL-1β among AMD patients and control.IL-1 β concentration were higher at control.Detection of high level of inflammatory cytokines supports a role for inflammation in AMD pathogenesis.

Key concepts: Macular degeneration, Disease, Medicine, Ophthalmology, Internal medicine

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
The Circulating Level of IL-1β in Patients with Age-related Macular Degeneration (AMD) in Yogyakarta: Characteristics to Disease Activity — Research Paper | ScholarLens