2021•Microbiology SpectrumOpen access
Caerin 1.1 and 1.9 Peptides from Australian Tree Frog Inhibit Antibiotic-Resistant Bacteria Growth in a Murine Skin Infection Model
Shu Chen, Pingping Zhang, Liyin Xiao, Ying Liu, Kuihai Wu, Guoying Ni, Hejie Li, Tianfang Wang, Xiaolian Wu, Guoqiang Chen, Xiaosong Liu
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Abstract
Antibiotic-resistant bacteria cause severe problems in the clinic. We show in our paper that two short peptides isolated from an Australian frog and prepared in the form of a gel are able to inhibit the growth of antibiotic-resistant bacteria in mice, and, unlike antibiotics, these peptides do not lead to the development of peptide-resistant bacteria strains.