2021•International Journal of PharmaceuticsOpen access

Continuous manufacture of hydroxychloroquine sulfate drug products via hot melt extrusion technology to meet increased demand during a global pandemic: From bench to pilot scale

Victoire de Margerie, Christopher F. McConville, Suha Dadou, Shu Li, Pascal Boulet, Lionel Aranda, Andrew Walker, Valentyn Mohylyuk, David S. Jones, Brian M. Murray, Gavin P. Andrews

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Key concepts: Plastics extrusion, SCALE-UP, Crystallinity, Extrusion, Materials science, Process engineering, Pharmaceutical manufacturing, Environmental science