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2020•Biomedical Journal of Scientific & Technical ResearchOpen access

Vaccine Development and Immunological Aspects of Ebola Virus Disease (EVD): An Update

Tauseef Ahmad, Taha Hussein Musa, Hui Jin, Tauseef Ahmad, Taha Hussein Musa, Hui Jin, Fazal Mehmood Khan, Muhammad S. Khan, Fazal Mehmood Khan, Alfonso J. Rodríguez‐Morales, Alfonso J. Rodríguez‐Morales

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Abstract

Infectious diseases emergence and re-emergence over the last 50 years have increased.Ebola virus disease (EVD) has been a public health emergency of international concern, given its high risk of transmission, and its high case-fatality rate can reach over 40%.The EVD first emerged in 1976.Epidemics, particularly since 2014, have called for interventions, mainly those preventive and the specific aim of developing an effective vaccine.There are currently no licensed vaccines available to prevent EVD infections.However, since the discovery of EVD, different vaccine strategies, including monovalent, bivalent, and multivalent candidates, have been studied.In such a critical time, the health care community played an active role by fast-tracking an EVD vaccine, which was not available to stop the outbreak.The outbreak intensity could be reduced much more if VSV-ZEBOV had been assessed for safety after the initial stages of the pre-clinical study.

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Infectious diseases emergence and re-emergence over the last 50 years have increased.Ebola virus disease (EVD) has been a public health emergency of international concern, given its high risk of transmission, and its high case-fatality rate can reach over 40%.The EVD first emerged in 1976.Epidemics, particularly since 2014, have called for interventions, mainly those preventive and the specific aim of developing an effective vaccine.There are currently no licensed vaccines available to prevent EVD infections.However, since the discovery of EVD, different vaccine strategies, including monovalent, bivalent, and multivalent candidates, have been studied.In such a critical time, the health care community played an active role by fast-tracking an EVD vaccine, which was not available to stop the outbreak.The outbreak intensity could be reduced much more if VSV-ZEBOV had been assessed for safety after the initial stages of the pre-clinical study.

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Available abstract

Infectious diseases emergence and re-emergence over the last 50 years have increased.Ebola virus disease (EVD) has been a public health emergency of international concern, given its high risk of transmission, and its high case-fatality rate can reach over 40%.The EVD first emerged in 1976.Epidemics, particularly since 2014, have called for interventions, mainly those preventive and the specific aim of developing an effective vaccine.There are currently no licensed vaccines available to prevent EVD infections.However, since the discovery of EVD, different vaccine strategies, including monovalent, bivalent, and multivalent candidates, have been studied.In such a critical time, the health care community played an active role by fast-tracking an EVD vaccine, which was not available to stop the outbreak.The outbreak intensity could be reduced much more if VSV-ZEBOV had been assessed for safety after the initial stages of the pre-clinical study.

Key concepts: China, Public health, Christian ministry, Biosafety, Epidemiology, Library science, Geography, Medicine

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