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2021•PubMedOpen access

Anti-planktonic and anti-biofilm effects of two synthetic anti-microbial peptides against Staphylococcus epidermidis.

Zhengli Hou, Biming Zhang, Pengfei She, Yuan Qing Wu, Ran Zhang

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Abstract

OBJECTIVES: is one of the most common Gram-positive cocci in nosocomial infection, which could adhere to the surface of medical apparatus and causes biofilm-related infections. In the present study, we aim to explore the antimicrobial effects of GH12 and SAAP-148 against METHODS: was detected by flow cytometry. Expressions of icaA and icaDgenes were analyzed by real-time reverse transcription PCR. RESULTS: . The expressions of icaA and icaDgenes were significantly inhibited by antimicrobial peptides at the 1×minimal inhibitory concentration. CONCLUSIONS: by disruption of cell membrane and inhibition of icaAand icaDgene expression.

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OBJECTIVES: is one of the most common Gram-positive cocci in nosocomial infection, which could adhere to the surface of medical apparatus and causes biofilm-related infections. In the present study, we aim to explore the antimicrobial effects of GH12 and SAAP-148 against METHODS: was detected by flow cytometry. Expressions of icaA and icaDgenes were analyzed by real-time reverse transcription PCR. RESULTS: . The expressions of icaA and icaDgenes were significantly inhibited by antimicrobial peptides at the 1×minimal inhibitory concentration. CONCLUSIONS: by disruption of cell membrane and inhibition of icaAand icaDgene expression.

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Available abstract

OBJECTIVES: is one of the most common Gram-positive cocci in nosocomial infection, which could adhere to the surface of medical apparatus and causes biofilm-related infections. In the present study, we aim to explore the antimicrobial effects of GH12 and SAAP-148 against METHODS: was detected by flow cytometry. Expressions of icaA and icaDgenes were analyzed by real-time reverse transcription PCR. RESULTS: . The expressions of icaA and icaDgenes were significantly inhibited by antimicrobial peptides at the 1×minimal inhibitory concentration. CONCLUSIONS: by disruption of cell membrane and inhibition of icaAand icaDgene expression.

Key concepts: Staphylococcus epidermidis, Biofilm, Microbiology, Staphylococcus aureus, Minimum inhibitory concentration, Staphylococcus, Minimum bactericidal concentration, Chemistry

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Anti-planktonic and anti-biofilm effects of two synthetic anti-microbial peptides against Staphylococcus epidermidis. — Research Paper | ScholarLens