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[Mast cell population in rats with experimental atherosclerosis].

Umarova Ba, Strukova Sm, Bazaz'ian Gg, Khlebnikova Tg, Kolokol'chikova Eg

Abstract

Mast cell population was studied in rats with experimental atherosclerosis. It has been established that animals kept for 8 months on atherogenic diet revealed marked changes in mast cell population. Predominance of light cells and cell defects were noted. Heparin saturation index was reduced (0.35), as compared to the control (3.9). Stimulation of anticoagulation system by DIP-alpha-thrombin in such animals revealed no heparin in the blood. Mast cell subpopulation was characterized by light cell predominance and low heparin saturation index. The nature of cell degradation remained unchanged. The data obtained indicate the defects in mast cell pool in animals with experimental atherosclerosis.

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Key concepts: Mast cell, Heparin, Cell, Population, Stimulation, Thrombin, Internal medicine, Endocrinology