232-OR: Replacing Sedentary Time by Different Types of Physical Activity and the Risk of Type 2 Diabetes

Background: Sedentary behaviors have been associated with an increased risk of type 2 diabetes (T2D). The newly released Physical Activity Guidelines for Americans also recommend replacing sedentary behaviors by physical activity. However, it is largely unknown which types of physical activity would be the healthy alternatives to sedentary behaviors, and to what extent it may reduce the risk of T2D. Methods: We prospectively analyzed the association between sedentary time and risk of T2D among 475,502 participants free of T2D in the UK Biobank. Sedentary time was quantified by summing up the time spent on television watching, computer using, and driving. Results: During a median follow-up of 11 years, we documented 18,169 incident T2D. Sedentary time were significantly associated with an increased risk of T2D (≥6 hours/day vs. <2 hours/day: hazard ratio [HR]: 1.58; 95% confidence interval (CI): 1.47~1.71). Such associations were more profound among women or obese participants (p-interaction<0.001 for both). Replacing 30 minutes/day sedentary time with different types of physical activities were significantly associated with a 6-31% lower risk of T2D, with strenuous sports (exercise making sweat or breathing hard) showing the strongest risk reduction (per 30 minutes/day: HR: 0.69; 95% CI: 0.63~0.76). Replacing sedentary time by structured exercise showed greater reduction (26%, 23-28%) of T2D risk than by daily-life activity (9%, 8-10%). Conclusions: Our study indicates that sedentary time combining watching TV, using computer and driving are independently associated with an increased risk of T2D; and replacing sedentary time with the structured exercise is related to greater reduction than with daily activity on T2D risk. Disclosure X. Li: None. T. Zhou: None. H. Ma: None. Y. Heianza: None. L. Qi: None.