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2017•NASA STI Repository (National Aeronautics and Space Administration)Open access

Gene Expression and Structural Skeletal Responses to Long-Duration Simulated Microgravity in Rats

Yasaman Shirazi‐Fard, Victoria E. Rael, Samantha M. Torres, Sonette Steczina, Sheenah Lynn Bryant, Candice Ginn T. Tahimic, Ruth K. Globus

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Abstract

In this study, we aim to examine skeletal responses to simulated long-duration spaceflight (90 days) and weight-bearing recovery on bone loss using the ground-based hindlimb unloading (HU) model in adolescent (3-month old) male rats. We hypothesized that simulated microgravity leads to the temporal regulation of oxidative defense genes and pro-bone resorption factors, where there is a progression and eventual plateau; furthermore, early transient changes in these pathways precede skeletal adaptations.

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What this paper is about

In this study, we aim to examine skeletal responses to simulated long-duration spaceflight (90 days) and weight-bearing recovery on bone loss using the ground-based hindlimb unloading (HU) model in adolescent (3-month old) male rats. We hypothesized that simulated microgravity leads to the temporal regulation of oxidative defense genes and pro-bone resorption factors, where there is a progression and eventual plateau; furthermore, early transient changes in these pathways precede skeletal adaptations.

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Available abstract

In this study, we aim to examine skeletal responses to simulated long-duration spaceflight (90 days) and weight-bearing recovery on bone loss using the ground-based hindlimb unloading (HU) model in adolescent (3-month old) male rats. We hypothesized that simulated microgravity leads to the temporal regulation of oxidative defense genes and pro-bone resorption factors, where there is a progression and eventual plateau; furthermore, early transient changes in these pathways precede skeletal adaptations.

Key concepts: Spaceflight, Hindlimb, Duration (music), Endocrinology, Weightlessness, Biology, Internal medicine, Bone resorption

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