Assessing Insulin Resistance Among Obese Children and Adolescents Glucose/Insulin Ratio and Quantitative Insulin Sensitivity Check Index for Homeostasis Model Assessment Is More Reliable Than the Fasting

ABSTRACT. Objective. Simple fasting methods tomeasure insulin resistance, such as the homeostasismodel assessment (HOMA), fasting glucose/insulin ratio(FGIR), and quantitative insulin sensitivity check index(QUICKI)methods,havebeenwidelypromotedforadultstudies but have not been evaluated formally amongchildren and adolescents. The aim of this study was tocompare the HOMA, FGIR, and QUICKI methods formeasuring insulin resistance, expressed by oral glucosetolerance test (OGTT) results, among obese children andadolescents. Methods. Fifty-seven pubertal obese children and ad-olescents (30 girls and 27 boys; mean age, 12.04 2.90years; mean BMI: 29.57 5.53) participated in the study.All participants underwent an OGTT. Blood sampleswere obtained 0, 30, 60, 90, and 120 minutes after oralglucose administration for glucose and insulin measure-ments, and 2 separate groups were studied, according tothe presence or absence of insulin resistance. HOMA,FGIR, and QUICKI methods were studied for validationof insulin resistance determined with the OGTT forthese groups.