2021•Microbial PathogenesisOpen access

Research progress on live attenuated vaccine against African swine fever virus

Le Liu, Xiangwei Wang, Ruoqing Mao, Yahua Zhou, Juanbin Yin, Yuefeng Sun, Xiangping Yin

Abstract

African swine fever (ASF) is an acute, hemorrhagic and severe infectious disease caused by African swine fever virus (ASFV) in domestic pigs and various wild boars, with a mortality rate up to 100%. ASF was first discovered in 1921 in Kenya. ASFV has a large genome and complex immune escape mechanism creating difficulties in the production of vaccines. Recently, remarkable advances have been made in vaccine development all over the world especially in live-attenuated vaccine. This article aims to review the research progress of ASF attenuated live vaccines in order to provide a reference for the development of vaccines for this disease.

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Key concepts: African swine fever virus, African swine fever, Attenuated vaccine, Virology, Virus, Immune system, Biology, Infectious disease (medical specialty)