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2021•IP Indian Journal of Clinical and Experimental DermatologyRequires access

Fever with rash; Role of an untold history in clinching the diagnosis

Kamath Pr, Bhat Rs, Patel Pv, Cholakundan Ab

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Abstract

Dapsone is a potent antimicrobial and anti-inflammatory compound, which is mainly used in the treatment of leprosy, neutrophilic dermatoses and a variety of blistering skin diseases. It is known to cause a severe adverse drug reaction presenting with fever, rash and multiorgan involvement known as Dapsone Hypersensitivity Syndrome (DHS). Here we report a case of near fatal fever, rash, and hepatitis secondary to dapsone. Keywords: Dapsone Hypersensitivity, Dapsone Syndrome, Leprosy, Multidrug Treatment

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What this paper is about

Dapsone is a potent antimicrobial and anti-inflammatory compound, which is mainly used in the treatment of leprosy, neutrophilic dermatoses and a variety of blistering skin diseases. It is known to cause a severe adverse drug reaction presenting with fever, rash and multiorgan involvement known as Dapsone Hypersensitivity Syndrome (DHS). Here we report a case of near fatal fever, rash, and hepatitis secondary to dapsone. Keywords: Dapsone Hypersensitivity, Dapsone Syndrome, Leprosy, Multidrug Treatment

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Available abstract

Dapsone is a potent antimicrobial and anti-inflammatory compound, which is mainly used in the treatment of leprosy, neutrophilic dermatoses and a variety of blistering skin diseases. It is known to cause a severe adverse drug reaction presenting with fever, rash and multiorgan involvement known as Dapsone Hypersensitivity Syndrome (DHS). Here we report a case of near fatal fever, rash, and hepatitis secondary to dapsone. Keywords: Dapsone Hypersensitivity, Dapsone Syndrome, Leprosy, Multidrug Treatment

Key concepts: Dapsone, Rash, Leprosy, Medicine, Dermatology, Hepatitis, Immunology

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