2021•Metabolic EngineeringRequires access
Metabolic Engineering ofEscherichiacoli
Zi Wei Luo, Jung Ho Ahn, Tong Un Chae, So Young Choi, Seon Young Park, Yoojin Choi, Jiyong Kim, Cindy Pricilia Surya Prabowo, Jong An Lee, Dongsoo Yang, Tae-Hee Han, Hanwen Xu, Sang Yup Lee
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Abstract
Metabolic engineering has become an essential technology for developing microbial cell factories for producing chemicals and materials from sustainable and renewable feedstocks. Equipped with the ever-advancing tools and strategies of modern systems biology and synthetic biology, traditional metabolic engineering has been upgraded to a next and systems level, which enables more rapid and sophisticated engineering of microbes for producing desired bioproducts. Escherichia coli has been playing a key role as a workhorse in the production of various chemicals and materials and also as a model bacterium in the development of advanced engineering tools and strategies. In this chapter, we review the achievements in metabolic engineering of E. coli for the biobased production of chemicals and materials together with accompanying tools and strategies.