1976•OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)Requires access
Intestinal retention and tissue distribution of /sup 141/Ce after oral administration in the suckling beagle dog. Studies on the metabolism of radioactive nuclide in the juvenile mammal, 2
R. Ichikawa, Yoshiyuki Shiraishi, Jiro Inaba, Yosuke Nishimura, Yuko Noda
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Abstract
The experiment was performed in order to investigate the intestinal retention and absorption of radiocerium in juvenile beagles and the result was compared with that obtained previously in the rat. /sup 141/Ce given orally was retained in the whole-body for more prolonged time by sucking than by weanlings or adults. Distribution study showed that the /sup 141/Ce was associated with the intestinal tract and a little was transferred to the organs other than the intestine. The present result was in accord with that in rats qualitatively. However, there are important differences of the /sup 141/Ce metabolism between beagles and rats which affects the intestinal dose calculation. The retention curve of /sup 141/Ce for beagle sucklings can be described exponentially and the levelling off of whole-body /sup 141/Ce retention occurs before the time of weaning, while the curve for rat sucklings has a so-called shoulder and the levelling off takes place at about weaning.