Comparison of dexmedetomidine vs labetalol for attenuation of haemodynamic stress responses to laryngoscopy and endotracheal intubation

Background: We hypothesized that the effectiveness of dexmedetomidine versus labetalol in attenuation of hemodynamic stress responses of laryngoscopy and intubation and effect of dexmedetomidine in post-operative sedation .Also we studied adverse effect of both the drugs.Method: Following approval by institutional ethics committee and 60 patients, who posted for elective surgeries under general anaesthesia taken. Study drug was given in 100 ml of saline over 10 mins. Inj dexmedetomine 1 microgram/ kg and Inj. labetalol 0.25 mg/kg given and parameters like HR, SBP, DBP, Spo2, and sedation score were monitored immediately and after 3,5 and 10 minutes.Result: There was a reduction in the heart rate and mean arterial pressure response to intubation in both Dexmedetomidine and labetalol but there was statistically significant reduction of heart rate and arterial pressure response to intubation in Dexmedetomidine group. There was statistically significant sedation in Dexmedetomidine group.Conclusion: Dexmedetomidine 1μ/Kg given slowly over 10 minutes intravenously 5 minutes prior to induction, attenuates the cardiovascular responses to laryngoscopy and intubation in a better manner than Labetalol 0.25mg/Kg.