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Synthesis and Chemistry of Lysergic Acid Derivatives. Part 1

Thomas C. Simmons, Ronald J. Kassel, Abraham Singer, David Burkhard, Thomas F. Kolesar

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Abstract

Abstract : The synthesis of D-lysergic acid diethylamide (LSD) from natural D- lysergic acid reported by investigators in 1943, and the accidential ingestion of a small amount of this material reported in 1947, led to the discovery of the unusual capacity of this drug to cause abnormal psychic phenomena in man. The document describes the production of LSD and its derivatives, methods of synthesis of LSD and other lysergic acid amides, the chemistry of LSD and related compounds, stability and analysis and its derivatives of LSD; 107 literature citations are listed.

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Abstract : The synthesis of D-lysergic acid diethylamide (LSD) from natural D- lysergic acid reported by investigators in 1943, and the accidential ingestion of a small amount of this material reported in 1947, led to the discovery of the unusual capacity of this drug to cause abnormal psychic phenomena in man. The document describes the production of LSD and its derivatives, methods of synthesis of LSD and other lysergic acid amides, the chemistry of LSD and related compounds, stability and analysis and its derivatives of LSD; 107 literature citations are listed.

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Available abstract

Abstract : The synthesis of D-lysergic acid diethylamide (LSD) from natural D- lysergic acid reported by investigators in 1943, and the accidential ingestion of a small amount of this material reported in 1947, led to the discovery of the unusual capacity of this drug to cause abnormal psychic phenomena in man. The document describes the production of LSD and its derivatives, methods of synthesis of LSD and other lysergic acid amides, the chemistry of LSD and related compounds, stability and analysis and its derivatives of LSD; 107 literature citations are listed.

Key concepts: Lysergic acid, Lysergic acid diethylamide, Chemistry, Psychic, Organic chemistry, Stereochemistry, Biochemistry, Medicine

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