2017•춘·추계 학술대회 (KASL)Requires access
O-096 : Improvement of Liver Function Parameters and Fibrosis Scores, APRI and FIB-4 in Hepatitis C Virus Infected Patients Treated with Direct-Acting Antiviral Agents
Hae Lim Lee, Sung Won Lee, Nam Ik Han, Hee Yeon Kim, Chang Wook Kim, Chan Ran You, Sang Wook Choi, Se Hyun Cho, Do Seon Song, U I. Chang, Jin Mo Yang, Sun Hong Yoo, Jung Hyun Kwon, Soon Woo Nam, Myeong Jun Song, Seawon Hwang, Pil Soo Sung, Jeong Won Jang, Si Hyun Bae, Jong Young Choi, Seung Kew Yoon
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Abstract
Aims: The advent of direct-acting antiviral agents (DAA) has enabled high sustained viral response (SVR) rates in hepatitis C virus (HCV) infected patients. We aimed to evaluate longitudinal changes in liver function parameters and fibrosis scores in patients who achieved SVR.
Methods: A total of 963 patients who received interferon free DAA combination ± ribavirin for HCV infection between December 2015 and February 2017 at the liver unit of the Catholic University of Korea were consecutively recruited. Patients with hepatocellular carcinoma, other liver diseases, or those who received liver transplantation were excluded. Four hundred and thirteen patients who achieved sustained viral response 12 weeks post treatment (SVR12) were analyzed and the parameters of liver function, AST to Platelet Index (APRI) and Fibrosis-4 (FIB-4) scores before treatment was compared to that of SVR12.
Results: Of the 413 patients, 308 (75%) patients had chronic hepatitis and 105 (25%) patients had liver cirrhosis. In the total patients, aspartate aminotransferase were decreased from 61 to 28 IU/L and alanine aminotransferase levels were decreased from 57 to 21 IU/L between baseline and 4 weeks post treatment (p<0.001, both). In the patients with chronic hepatitis, APRI and FIB-4 scores were all significantly improved; APRI score was 0.93±1.28 and 0.51±0.56, p<0.001, FIB-4 score was 3.25±3.79 and 2.67±2.21, p=0.022, (mean±SD), at baseline and SVR12, respectively. In the patients with liver cirrhosis, platelet (PLT), albumin, prothrombine time international normalized ratio (PT INR) levels, APRI and FIB-4 scores were all significantly improved; PLT level was 115±53 and 166±82, p<0.001, albumin level was 3.8±0.6 and 4.3±0.3, p<0.001, PT INR level was 1.15±0.13 and 1.05±0.09, p<0.001, APRI score was 2.13±1.59 and 0.55±0.42, p<0.001, FIB-4 score was 7.83±5.56 and 2.79±1.73, p<0.001, at baseline and SVR12, respectively (mean±SD).
Conclusions: This study suggested that a significant improvement in liver function parameters and non-invasive fibrosis markers could be achieved in HCV infected patients who achieved SVR.