원저 ( Original Articles ) ; 아데닌과 살리실산 유도체와의 분자간 상호작용

Spectroscopic investigation has been carried out to know the binding mechanism of 9-ethyladenine with salicylic acid derivatives, such as salicylic acid, aspirin and salicylamide in chloroform solution by using infrared and nuclear magnetic resonance spectra. Adenine and salicylic acid form a 1:1 cyclic hydrogen bonded dimer in low concentration, but form a 2:1 (salicylic acid:adenine:salicylic acid) complex in high concentration. The high concentration of the sample demanded by NMR measurement has enabled us to observe this trimer formation, whereas the dilution necessary for IR method yields a concentration of trimer too small to be observed. In the case of aspirin, it is expected that the similar mode of the interaction with salicylic acid may occur because of its structural analogy with SA. The association between adenine and salicylamide is very weak unlike salicylic acid or aspirin. So, we cannot observe that 2-salicylamide: 1-adenine complex is present. Adenine and salicylamide form a 1:1 cyclic hydrogen bonded dimer. It appeared that salicylic acid forms the strongest complex among them, aspirin is second and then sailcylamide is third.