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2021•Journal of Travel MedicineOpen access

Single-dose pentamidine substantially reduces viability of trypanosomes in human East African trypanosomiasis

Perry J.J. van Genderen, Jan L Nouwen, Mariana de Mendonça Melo, Bart J. A. Rijnders, Jaap J. van Hellemond

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Abstract

Examination of viability of trypomastigotes before and after single-dose pentamidine treatment demonstrated that single-dose pentamidine substantially affected motility of trypomastigotes, a proxy of drug efficacy. This suggests that single-dose pentamidine may be of added value to bridge time until suramin will be available for treatment of human East Africa trypanosomiasis.

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Examination of viability of trypomastigotes before and after single-dose pentamidine treatment demonstrated that single-dose pentamidine substantially affected motility of trypomastigotes, a proxy of drug efficacy. This suggests that single-dose pentamidine may be of added value to bridge time until suramin will be available for treatment of human East Africa trypanosomiasis.

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Available abstract

Examination of viability of trypomastigotes before and after single-dose pentamidine treatment demonstrated that single-dose pentamidine substantially affected motility of trypomastigotes, a proxy of drug efficacy. This suggests that single-dose pentamidine may be of added value to bridge time until suramin will be available for treatment of human East Africa trypanosomiasis.

Key concepts: Pentamidine, Suramin, African trypanosomiasis, Trypanosomiasis, Medicine, Diminazene, Pharmacology, Virology

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Single-dose pentamidine substantially reduces viability of trypanosomes in human East African trypanosomiasis — Research Paper | ScholarLens