Assessment of Serum Lipid and Uric Acid Levels in Women with Normal Pregnancy and Pre-Eclampsia

OBJECTIVES: To determine and compare the serum lipid profile and uric acid concentration in pre-eclamptic and normal pregnant women.METHODOLOGY: This cross sectional study was carried out at Biochemistry Department, LUMHS Jamshoro with the collaboration of Gynaecology and Obstetrics Department and Diagnostic & Research Laboratory, Pathology Department, LUMHS Jamshoro from March 2016 to December 2016.Patients were selected via non-probability consecutive sampling.A total of 60 subjects were enrolled and divided into two groups comprising women with normal pregnancy(n=30) as controls and women with pre-eclampsia (n=30) as cases after applying exclusion criteria.RESULTS: Mean age of women with pre-eclampsia and normal pregnancy was found to be 26.77±2.58and 26.30±2.05years (p-value=0.44).Significantly higher levels (p-value < 0.05) of triglycerides (TG), total cholesterol (TC), low density lipoproteins (LDL) and serum uric acid were found in the women with pre-eclampsia as compared to controls; whereas, high density lipoproteins (HDL) were significantly lowered (p-value < 0.05) in women with pre-eclampsia.Uni-variate analysis showed that the TG (OR=7.67),TC (OR=3 and 5.55), LDL (OR=3.59)and uric acid (OR=11.23)were significantly increased and HDL (OR= 9.75) were significantly lowered in women with pre-eclampsia than in women with normal pregnancy (p-value < 0.05).In the multi-variate logistic model, TG (OR=4.28)and uric acid (OR=6.62)were significantly increased and HDL (OR= 4.31)were significantly lowered in women with pre-eclampsia than in women with normal pregnancy (p-value<0.05)CONCLUSION: Alteration in the serum uric acid and TG concentration may be helpful in early detection and monitoring of pre-eclampsia cases.This information may be utilized in preventing the adverse outcomes occurring as a result of pre-eclampsia.