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Allogeneic transplantation for multiple myeloma

Ignazio Majolino, E. Carnevall, Anna Locasciulli, Paolo Di Bartolomeo, Rosanna Scimè, Paolo Corradini, Carmine Selleri, Franco Narni, Maurizio Musso, Marco Bregni, Attilio Olivieri, Paolo de Fabritiis, Luigi Pogliani, J. E. Duque-Arbelaez, Carla Ruscio, Andrea Paolo Bacigalupo

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Abstract

In this review the authors present a state of art tretment of multiple myeloma.High dose chemo-radiotherapy followed by autologous hematopoietic stem cell transplantation has been show to be superior a conventional chemotherapy and a double transplantation. The authors discuss too, the allogeneic transplantation with reduced intensity conditioning, allogeneic versus tandem autologous, results the patients long term outcome and a approach about the use of donor lymphocytes, anti thimocyte globulin and a overview of post transplant therapies.

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What this paper is about

In this review the authors present a state of art tretment of multiple myeloma.High dose chemo-radiotherapy followed by autologous hematopoietic stem cell transplantation has been show to be superior a conventional chemotherapy and a double transplantation. The authors discuss too, the allogeneic transplantation with reduced intensity conditioning, allogeneic versus tandem autologous, results the patients long term outcome and a approach about the use of donor lymphocytes, anti thimocyte globulin and a overview of post transplant therapies.

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Available abstract

In this review the authors present a state of art tretment of multiple myeloma.High dose chemo-radiotherapy followed by autologous hematopoietic stem cell transplantation has been show to be superior a conventional chemotherapy and a double transplantation. The authors discuss too, the allogeneic transplantation with reduced intensity conditioning, allogeneic versus tandem autologous, results the patients long term outcome and a approach about the use of donor lymphocytes, anti thimocyte globulin and a overview of post transplant therapies.

Key concepts: Multiple myeloma, Transplantation, Medicine, Immunology, Internal medicine

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