Efficacy of Intra-vitreal Bevacizumab for Resolution of Macular Edema Secondary to Central Retinal Vein Occlusion

Purpose: To determine the efficacy of intravitreal injection of Bevacizumab inresolution of macular edema in patients of central retinal vein occlusion.Material and Methods: It was a descriptive case series, conducted at Instituteof Ophthalmology unit III, Mayo Hospital Lahore and Bahawal – Victoria HospitalBahawalpur simultaneously. A total of 60 cases were selected though purposivesampling for this study. Diagnosis was ascertained on fundus fluoresceinangiography. Pre and post injection macular edema was measured on opticalcoherence tomography on the day of drug administration and thirty days after it.Results: Mean macular thickness before treatment was 663.10 ± 109.76microns and after treatment mean thickness was 453.06 ± 106.09 microns whichwas a significant (p = 0.0000001) finding. Majority (75%) of patients achieved areduction of ≥ 200 microns in their retinal thickness after treatment. Whereas inthe remaining 15 (25%) patients reduction in retinal thickness was < 200microns. These findings were independent of gender bias.Conclusion: Intravitreal injection of Bevacizumab is effective in the resolution ofmacular edema in the patients of central retinal vein occlusion.Key words: Central retinal vein occlusion, macular edema, Bevacizumab.