ScholarLens Back to search
1999•PROGRESS IN BIOCHEMISTRY AND BIOPHYSICSRequires access

Pitx2: a left right Asymmetric Signalling Molecule.

Liu Ji, Wbl Peking

Open publisher page 0 citations

Abstract

Pitx2 is asymmetrically expressed in the left lateral plate mesoderm and derived organs such as heart and gut during chick, mouse and Xenopus development . Pitx2 appears to be downstream effector of Shh and Nodal. Misexpression of Pitx2 is sufficient to produce reversed organs of body rotation. Defect of Pitx2 in human may cause Rieger syndrome . Pitx2 seems to be a key conserved signalling molecules that mediates left right asymmetry in vertebrate.

About this research paper

What this paper is about

Pitx2 is asymmetrically expressed in the left lateral plate mesoderm and derived organs such as heart and gut during chick, mouse and Xenopus development . Pitx2 appears to be downstream effector of Shh and Nodal. Misexpression of Pitx2 is sufficient to produce reversed organs of body rotation. Defect of Pitx2 in human may cause Rieger syndrome . Pitx2 seems to be a key conserved signalling molecules that mediates left right asymmetry in vertebrate.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Pitx2 is asymmetrically expressed in the left lateral plate mesoderm and derived organs such as heart and gut during chick, mouse and Xenopus development . Pitx2 appears to be downstream effector of Shh and Nodal. Misexpression of Pitx2 is sufficient to produce reversed organs of body rotation. Defect of Pitx2 in human may cause Rieger syndrome . Pitx2 seems to be a key conserved signalling molecules that mediates left right asymmetry in vertebrate.

Key concepts: PITX2, Xenopus, NODAL, Lateral plate mesoderm, Biology, Effector, Mesoderm, Cell biology

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Pitx2: a left right Asymmetric Signalling Molecule. — Research Paper | ScholarLens