2011•Jiangsu Medical JournalRequires access

Effects of edaravone on MDA SOD and GSH in patients with shock after burn

Ju Zou

Abstract

Objective To investigate the anti-oxygen free radical effect of edaravone in acute lung injury(ALI) of patients with shock after severe burn.Methods The shocked patients after burn were randomly divided into three groups A(shock control),B(edaravone treatment) and C(normal saline control) with 7 cases each.The levels of oxygen free radicals were evaluated by measuring serum malondialdehyde(MDA),superoxide dismutase(SOD) and γ-glutamylcysteinylglycine(GSH).Results MDA level was significantly lower,but SOD and GSH levels were significantly higher in group B than those in group A(P0.01).Conclusion Edaravone has preventive effect on ALI of patients with shock after severe burn through its anti-oxygen free radical efficacy.

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Key concepts: Edaravone, Malondialdehyde, Superoxide dismutase, Medicine, Radical, Shock (circulatory), Anesthesia, Antioxidant