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2014•Journal of Jianghan UniversityRequires access

Sorafenib Combined with Recombinant Human TRAIL on Growth Inhibition Effects and Inducing Apoptosis of Leukemia Cells of K562

Wang Ahu

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Abstract

Objective To investigate the different effect of Sorafenib and TRAIL on proliferationinhibition and apoptosis inducing of K562 cells.Methods Inhibition of K562 cells proliferationby Sorafenib alone and combined with TRAIL were studied in vitro using CCK-8. Apoptosis induc-ing rate of K562 cells by Sorafenib alone and combined with TRAIL were accessed by Western-Blotdetection.Results Combination with Sorafenib and TRAIL synergistically increased the growthinhibition effects and enhanced the apoptosis rate of K562 cells.Conclusion Combination treat-ment of Sorafenib and TRAIL showed a synergistic anti-proliferative effect in K562 cells.

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What this paper is about

Objective To investigate the different effect of Sorafenib and TRAIL on proliferationinhibition and apoptosis inducing of K562 cells.Methods Inhibition of K562 cells proliferationby Sorafenib alone and combined with TRAIL were studied in vitro using CCK-8. Apoptosis induc-ing rate of K562 cells by Sorafenib alone and combined with TRAIL were accessed by Western-Blotdetection.Results Combination with Sorafenib and TRAIL synergistically increased the growthinhibition effects and enhanced the apoptosis rate of K562 cells.Conclusion Combination treat-ment of Sorafenib and TRAIL showed a synergistic anti-proliferative effect in K562 cells.

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Available abstract

Objective To investigate the different effect of Sorafenib and TRAIL on proliferationinhibition and apoptosis inducing of K562 cells.Methods Inhibition of K562 cells proliferationby Sorafenib alone and combined with TRAIL were studied in vitro using CCK-8. Apoptosis induc-ing rate of K562 cells by Sorafenib alone and combined with TRAIL were accessed by Western-Blotdetection.Results Combination with Sorafenib and TRAIL synergistically increased the growthinhibition effects and enhanced the apoptosis rate of K562 cells.Conclusion Combination treat-ment of Sorafenib and TRAIL showed a synergistic anti-proliferative effect in K562 cells.

Key concepts: Sorafenib, K562 cells, Apoptosis, Leukemia, In vitro, Cancer research, Pharmacology, Growth inhibition

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