Review of the biomarker research of acrylamide reproductive and developmental toxicity

Acrylamide(AA) is primarily generated in starchy food which heated up to 120 ℃. Researches showed that AA had reproductive toxicity, developmental toxicity, neurotoxicity and genetic toxicity to the body. Especially, the reproductive and developmental toxicity of AA attracted a great of attentions gradually. In the research of reproductive toxicity and developmental toxicity of AA, any indexes reflected reproductive system damage could be used as biomarkers of AA reproductive toxicity. As the same, any indexes reflected developmental system damage could also be used as biomarkers of AA developmental toxicity. As more and more biomarkers have been determined, they will play an important role in the risk assessment. Therefore, the evaluation of biomarker has very important significance in comprehensive research of AA reproductive and developmental toxicity. This paper reviewed the biomarker of reproductive and developmental toxicity of AA, and described them from various perspectives.