2014Chinese Journal of Reparative and Reconstructive SurgeryRequires access

APPLICATION OF SILK FIBROIN SCAFFOLD IN BONE TISSUE ENGINEERING

LU Shiju

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Abstract

Objective To review the application of silk fibroin scaffold in bone tissue engineering. Methods The related literature about the application of silk fibroin scaffold in bone tissue engineering was reviewed, analyzed, and summarized. Results Silk fibroin can be manufactured into many types, such as hydrogel, film, nano-fiber, and threedimensional scaffold, which have superior biocompatibility, slow biodegradability, nontoxic degradation products, and excellent mechanical strength. Meanwhile these silk fibroin biomaterials can be chemically modified and can be used to carry stem cells, growth factors, and compound inorganic matter. Conclusion Silk fibroin scaffolds can be widely used in bone tissue engineering. But it still needs further study to prepare the scaffold in accordance with the requirement of tissue engineering.

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What this paper is about

Objective To review the application of silk fibroin scaffold in bone tissue engineering. Methods The related literature about the application of silk fibroin scaffold in bone tissue engineering was reviewed, analyzed, and summarized. Results Silk fibroin can be manufactured into many types, such as hydrogel, film, nano-fiber, and threedimensional scaffold, which have superior biocompatibility, slow biodegradability, nontoxic degradation products, and excellent mechanical strength. Meanwhile these silk fibroin biomaterials can be chemically modified and can be used to carry stem cells, growth factors, and compound inorganic matter. Conclusion Silk fibroin scaffolds can be widely used in bone tissue engineering. But it still needs further study to prepare the scaffold in accordance with the requirement of tissue engineering.

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Available abstract

Objective To review the application of silk fibroin scaffold in bone tissue engineering. Methods The related literature about the application of silk fibroin scaffold in bone tissue engineering was reviewed, analyzed, and summarized. Results Silk fibroin can be manufactured into many types, such as hydrogel, film, nano-fiber, and threedimensional scaffold, which have superior biocompatibility, slow biodegradability, nontoxic degradation products, and excellent mechanical strength. Meanwhile these silk fibroin biomaterials can be chemically modified and can be used to carry stem cells, growth factors, and compound inorganic matter. Conclusion Silk fibroin scaffolds can be widely used in bone tissue engineering. But it still needs further study to prepare the scaffold in accordance with the requirement of tissue engineering.

Key concepts: Fibroin, Scaffold, Tissue engineering, SILK, Biocompatibility, Biomedical engineering, Bone tissue, Materials science

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