Study on the association between interleukin-5 and eosinophil in nasal polyp

Objective:To explore the expression of IL-5 and its role in the formation and development of nasal polyp.Method:31 patients with nasal polyp,11 patients with chronic sinusitis(CS) and 6 control cases were chosen .Their IL-5 concentration in tissue homogenate were measured by ELISA.All patients with chronic sinusitis,control cases and 15 patients with nasal polyp were chosen to be counted eosinophils in their HE slice. Result:①The values of IL-5(pg/ml) in nasal polyp,CS and control group separately were: 23.44 ± 6.68 , 16.41 ± 3.09 , 12.86 ± 4.17 .IL-5 concentration in nasal polyp group was higher than that in the other two groups(P 0.001 ).②The numbers of eosinophils in nasal polyp ,CS and control group were 7.42 ± 2.33 , 1.30 ± 0.59 , 1.07 ± 0.70 separately,the numbers of eosinophils in nasal polyp group were higher than that in CR or control group(P 0.05 ).Conclusion:Nasal polyp is a disease characterized by eosinophilia,and IL-5 which activates eosinophil plays part role in the formation of nasal polyp.