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Tumor angiogenesis and signal transduction via vascular endothelial growth factor receptor

Tan Wenfu, Dong Xiao, Jialong Wang, Jian Ding

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Abstract

Vascular endothelial growth factor (VEGF) plays a central role in tumor angiogenesis. It stimulates endothelial cell proliferation and vessel hyperpermeability, promotes cell migration, and inhibits apoptosis. All these actions of VEGF are mediated by receptor tyrosine kinase, vascular endothelial growth factor receptor (VEGFR). Selective targeting VEGFR signal transduction pathway may be proved to be useful in developing tumor angiogensis inhibitors.

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What this paper is about

Vascular endothelial growth factor (VEGF) plays a central role in tumor angiogenesis. It stimulates endothelial cell proliferation and vessel hyperpermeability, promotes cell migration, and inhibits apoptosis. All these actions of VEGF are mediated by receptor tyrosine kinase, vascular endothelial growth factor receptor (VEGFR). Selective targeting VEGFR signal transduction pathway may be proved to be useful in developing tumor angiogensis inhibitors.

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Available abstract

Vascular endothelial growth factor (VEGF) plays a central role in tumor angiogenesis. It stimulates endothelial cell proliferation and vessel hyperpermeability, promotes cell migration, and inhibits apoptosis. All these actions of VEGF are mediated by receptor tyrosine kinase, vascular endothelial growth factor receptor (VEGFR). Selective targeting VEGFR signal transduction pathway may be proved to be useful in developing tumor angiogensis inhibitors.

Key concepts: Vascular endothelial growth inhibitor, Angiogenesis, Vascular endothelial growth factor C, Vascular endothelial growth factor B, Signal transduction, Vascular endothelial growth factor, Cancer research, Vascular endothelial growth factor A

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