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Study of HPV16/18 Infection and Expression of Multiple Oncogene Product in Cervical Squamous Carcinoma

Li Huang

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Abstract

Objective To study the infection of HPV16/18 and the presence of multiple oncogene on the carcinogenesis of cervical squamous carcinoma.Methods Immunohistochemical method was used to detect E6?PCNA?p53?p 21ras and c myc protein expression in 19 cases of chronic cervicitis?40 cases of cervical intraepithelial neoplasm (CIN) and 70 cases of invasive cervical carcinoma.Results A high positive expression rate of E6?PCNA?p53?p 21ras was found in CINⅢ and invasive cervical carcinoma which c myc positive expression rate was significantly lower than chronic cervicitis?CINⅠ and CINⅡ.Conclusion HPV16/18 infection and the abnormal expression of PCNA?p53?p 21ras ?c myc may play an important role in the carcinogenesis of cervical squamous carcinoma.

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What this paper is about

Objective To study the infection of HPV16/18 and the presence of multiple oncogene on the carcinogenesis of cervical squamous carcinoma.Methods Immunohistochemical method was used to detect E6?PCNA?p53?p 21ras and c myc protein expression in 19 cases of chronic cervicitis?40 cases of cervical intraepithelial neoplasm (CIN) and 70 cases of invasive cervical carcinoma.Results A high positive expression rate of E6?PCNA?p53?p 21ras was found in CINⅢ and invasive cervical carcinoma which c myc positive expression rate was significantly lower than chronic cervicitis?CINⅠ and CINⅡ.Conclusion HPV16/18 infection and the abnormal expression of PCNA?p53?p 21ras ?c myc may play an important role in the carcinogenesis of cervical squamous carcinoma.

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Available abstract

Objective To study the infection of HPV16/18 and the presence of multiple oncogene on the carcinogenesis of cervical squamous carcinoma.Methods Immunohistochemical method was used to detect E6?PCNA?p53?p 21ras and c myc protein expression in 19 cases of chronic cervicitis?40 cases of cervical intraepithelial neoplasm (CIN) and 70 cases of invasive cervical carcinoma.Results A high positive expression rate of E6?PCNA?p53?p 21ras was found in CINⅢ and invasive cervical carcinoma which c myc positive expression rate was significantly lower than chronic cervicitis?CINⅠ and CINⅡ.Conclusion HPV16/18 infection and the abnormal expression of PCNA?p53?p 21ras ?c myc may play an important role in the carcinogenesis of cervical squamous carcinoma.

Key concepts: Carcinogenesis, Immunohistochemistry, Oncogene, Cervicitis, Cervical intraepithelial neoplasia, Cervical carcinoma, Proliferating cell nuclear antigen, Medicine

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Study of HPV16/18 Infection and Expression of Multiple Oncogene Product in Cervical Squamous Carcinoma — Research Paper | ScholarLens