STUDY ON THE THERAPEUTIC EFFECT OF FDP ON ARDS INDUCED BY OLEIC ACID IN RATS

[Objective] To study the therapeutic effect of Fructose-1, 6-diphosphate (FDP) on acute respiratory distress syndrome (ARDS) in rats induced by oleic acid (OA). [Methods] 30 healthy Wistar rats were randomly divided into three groups: Control group, ARDS group, FDP-treated group. Control group: injected normal saline (NS, 2.1ml / kg). ARDS group: injected oleic acid ( 0.1ml / kg) and NS ( 2.0ml / kg). Treatment group: injected oleic acid ( 0.1ml / kg) and FDP (400mg / kg, diluted in 2.0ml / kg of NS). 3 hours later, the MDA level in lung tissue, the wet-dry weigh ratio in left lung tissue were measured, and pulmonary pathological changes were compared among the three groups. [Results] Compared with control group, the wet-dry weigh ratio of left lung tissue in ARDS group increased significantly, as well as the level of MDA in lung tissue, and the activity of SOD in lung tissue decreased significantly and more typical pathological changes in lung tissue occurred when treated by OA .And the changes in FDP-treated group were better than in ARDS group. [Conclusion] FDP can inhibit the increase of MDA in lung tissue, also can increase the activity of SOD in lung tissue. FDP has theraputic effects on ARDS rats induced by OA.