2015•Acta Scientiarum Naturalium Universitatis SunyatseniRequires access

Hypercholesterolemia, low density lipoprotein receptor and proprotein convertase subtilisin/kexin-type 9

Hongmei, Gu, Dawei, Zhang

Abstract

动脉粥样硬化患者心血管的疾病在世界上是死亡和病态的主要原因。低密度脂蛋白胆固醇(LDL-C ) 的血浆层次断然与动脉粥样硬化的风险被相关。在有血胆脂醇过多的病人的高血浆 LDL 集中在动脉的内部墙中导致 LDL 的逐渐增加，它变得氧化并且支持泡沫房间的形成，因而开始动脉粥样硬化。血浆 LDL 主要通过 LDL 受体(LDLR ) 被清除小径。在 LDLR 的变化引起熟悉的血胆脂醇过多并且增加早熟的冠的心疾病的风险。LDLR 的表示经由甾醇在 transcriptional 水平被调整规章的元素绑定蛋白质 2 (SREBP-2 ) 并且在主要通过 proprotein convertase subtilisin/kexin-type 的 posttranslational 层次 9 (PCSK9 ) 并且 LDLR (偶像) 的可诱导的 degrader。在这评论，我们在 PCSK9 的研究总结最近的进展。

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Key concepts: Kexin, PCSK9, Proprotein convertase, LDL receptor, Subtilisin, Familial hypercholesterolemia, Internal medicine, Low-density lipoprotein