2015•Acta Scientiarum Naturalium Universitatis SunyatseniRequires access
Molecular mechanism of hepatitis B virus X protein function in hepatocarcinogenesis
Ming Ming, Geng Geng, Xuan Xuan, Xin, Liquan, Guoan Bi, Lu-Ting, Zhou, Xiaohong, Liu
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Abstract
Many factors are considered to contribute to hepatitis B virus(HBV)-associated hepatocellular carcinoma(HCC),including products of HBV,HBV integration and mutation,and host susceptibility. HBV X protein(HBx) can interfere with several signaling pathways associated with cell proliferation and invasion,and HBx C-terminal truncation has been suggested to impact the development of HCC. This review focuses on the pathological functions of HBx in HBV-induced hepatocarcinogenesis. As a transactivator,HBx can affect regulatory non-coding RNAs(nc RNAs),including micro RNAs and long nc RNAs. HBx is also involved in epigenetic modification and DNA repair. HBx interacts with various signal-transduction pathways,such as the p53,Wnt,and nuclear factor-κB pathways. We conclude that HBx hastens the development of hepatoma.