Novel insights into the Pathophysiology of Group II Pulmonary Hypertension Impact on the pulmonary vasculature and right ventricle

This thesis describes novel insights into pathophysiological mechanisms in pulmonary hypertension as a result of problems of the left heart. The author investigated why some patients deteriorate, even when the initial cause of the disease is cured. Furthermore, several pharmacotherapeutic approaches to stop the deterioration were tested.