Effect of different compatibility of tetramethylpyrazine on its pharmacokinetics in vivo

Objective: To study the pharmacokinetics of single administration and different compatibility of tetramethylpyrazine(TMP) in rats.Method: Thirty two Sprague-Dawley rats were randomly divided into 4 groups: the TMP(30 mg·kg-1) group,the TMP+FA(30 mg·kg-1+50 mg·kg-1) group,the TMP+TET(30 mg·kg-1+20 mg·kg-1) group and the TMP+FA+TET(30 mg·kg-1+ 50 mg·kg-1 +20 mg·kg-1) group.After the oral administration,their blood samples were collected to detect plasmas concentrations by HPLC method and to calculate pharmacokinetic parameters DAS 2.0 program.Result: In compatibility with FA,AUC 0-t,Cmax and Tmax showed no significant difference with the single administration of TMP,but t1/2 and MRT0-t were obviously longer than the single administration.In compatibility with TET and FA+TET,AUC 0-t,Cmax and Tmax showed significant increase than the single administration of TMP,whereas t1/2 and MRT0-t did not notably vary from the single administration.Conclusion: FA can prolong TMP′s action time in rats,and TET can accelerate TMP′s absorption in rats.