The expression of matrix metalloproteinase-2 and matrix metalloproteinase-9 in endometrial adenocarcinoma and the relations of clinical and prognosis

Objective To study the relationship between the expression of matrix metalloproteinase (MMP)-2 and -9 in endometrial endometrial adenocarcinoma normal endometrial tissue and clinical and prognosis of the disease. Methods The expression of MMP-2 and MMP-9 were examined in 100 patients with endometrial adenocarcinoma Between October of 2005 and March of 2009 in Zhongshan Hospital Affihated to Sun Yat-sen University by immunohistochemistry (EnVision method). We used 30 normal endometrial tissue as control. Results The normal endometrium mesenchymal and the epithelial cell may secrete MMPs,MMP-2,9,in the normal endometrium proliferative phase expression increases,but in the secretory phase nearly early does not have the expression (P0. 05). The expression of MMP-2 and MMP-9 in endometrial adenocarcinoma was significantly stronger than that in normal endometrial (P0.05).The expression of MMP-2 and MMP-9 in endometrial adenocarcinoma tissues was increased with advanced clinical stages and pathological grades (P0.05). As compared to the patiens without lymph node metastasis,the expressions of MMP-2 and MMP-9 in endometrial carcinoma was significantly higher than that in patients with lymph node metastasis. The expression of MMP-2 and MMP-9 was positively correlated (r= 0.545,P 0.01). The expression MMP-2 and MMP-9 was correlated with patient survival (P0.05). Conclusion MMP-2 and MMP-9 might promote the development of endometrial adenocarcinoma. The expression of MMP-2 and MMP-9 in endometrial adenocarcinoma was related to the clinical stages,pathological grades,and lymph node metastasis and can be used to predict the prognosis of endometrial adenocarcinoma.