2010•Acta Scientiarum Naturalium Universitatis SunyatseniRequires access

Emodin enhances alveolar epithelial barrier function in rats with experimental acute pancreatitis

Xia, Xianming, Wang, Fang-Yu, Zhen-Kai, Wan, Haijun, Xü, Wen-An, LU LU, Heng

Abstract

AIM: To investigate the effect of emodin on expression of claudin4, claudin5 and occludin, as well as the alveolar epithelial barrier in rats with pancreatitis induced by sodium taurocholate. METHODS: Experimental pancreatitis was induced by retrograde injection of 5% sodium taurocholate into the biliopancreatic duct. Emodin was injected via the external jugular vein 3 h after induction of acute pancreatitis. Rats from sham operation group and acute pancreatitis group were injected with normal saline (an eq...

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Key concepts: Emodin, Acute pancreatitis, Pancreatitis, Saline, Occludin, Pancreatic duct, Barrier function, Medicine