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- Cartilage Tissue Engineering

John P. Fisher, Antonios G. Mikos, Joseph D. Bronzino, Donald R. Peterson

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Abstract

Articular cartilage is complex in its extracellular matrix (ECM) organization in as well as cellular phenotype. e tissue is composed of predominately type II collagen, proteoglycans, and chondrocytes. However, the morphology and metabolic activity of the cells as well as the structure of the ECM vary greatly throughout the tissue depth. is intricate tissue organization allows cartilage to optimally resist loading and provide low-friction joint movement throughout a lifetime.

About this research paper

What this paper is about

Articular cartilage is complex in its extracellular matrix (ECM) organization in as well as cellular phenotype. e tissue is composed of predominately type II collagen, proteoglycans, and chondrocytes. However, the morphology and metabolic activity of the cells as well as the structure of the ECM vary greatly throughout the tissue depth. is intricate tissue organization allows cartilage to optimally resist loading and provide low-friction joint movement throughout a lifetime.

Why it matters

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Method / approach

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Available abstract

Articular cartilage is complex in its extracellular matrix (ECM) organization in as well as cellular phenotype. e tissue is composed of predominately type II collagen, proteoglycans, and chondrocytes. However, the morphology and metabolic activity of the cells as well as the structure of the ECM vary greatly throughout the tissue depth. is intricate tissue organization allows cartilage to optimally resist loading and provide low-friction joint movement throughout a lifetime.

Key concepts: Cartilage, Tissue engineering, Biomedical engineering, Computer science, Anatomy, Medicine

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