2009•Unpublished venueRequires access

Comparison of two kinds of models of immune thrombocytopenic purpura in mice

Da Li

Abstract

Objective:To analyze two different kinds of mouse model with immune thrombocytopenic purpura for the immune mechanisms.Methods:Immune thrombocytopenic purpura was induced by either injection of polyclonal antibody or immunized inoculation with rat platelets.Results:The two kinds of model all induced decrease of platelets,while immunization with platelets of rat induced alloantibodies in the mice.Conclusion:Immunization with platelets of rat can mimic the production process of autoantibodies in human and lead to immune thrombocytopenic purpura in mice.

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Key concepts: Thrombocytopenic purpura, Immune system, Platelet, Immunization, Immunology, Polyclonal antibodies, Antibody, Autoantibody