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2013•Chinese Journal of Reparative and Reconstructive SurgeryRequires access

RESEARCH PROGRESS OF A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIF 4 AND 5 IN OSTEOARTHRITIS

JI Quanb

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Abstract

Objective To review the progress of a disintegrin and metalloproteinase with thrombospondin motif 4(ADAMTS-4) and ADAMTS-5 in osteoarthritis.Methods Recent literature about the ADAMTS-4 and-5 in osteoarthritis was analyzed;the structure,function,inhibitors of the ADAMTS-4 and-5,and the relationship between the proteases and osteoarthritis were analyzed and summarized.Results ADAMTS-4 and-5 can reduce chondrocyte and extracellular matrix by degrading aggrecan and cartilage oligomeric matrix protein,which induced the pathogenesis of osteoarthritis.Conclusion ADAMTS-4 and-5 have been demonstrated to play important roles in osteoarthritis.It can better guide treatment and prevention of osteoarthritis to further study related mechanism of ADAMTS-4 and-5,and to promote the establishment of a clinical drug targets.

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Objective To review the progress of a disintegrin and metalloproteinase with thrombospondin motif 4(ADAMTS-4) and ADAMTS-5 in osteoarthritis.Methods Recent literature about the ADAMTS-4 and-5 in osteoarthritis was analyzed;the structure,function,inhibitors of the ADAMTS-4 and-5,and the relationship between the proteases and osteoarthritis were analyzed and summarized.Results ADAMTS-4 and-5 can reduce chondrocyte and extracellular matrix by degrading aggrecan and cartilage oligomeric matrix protein,which induced the pathogenesis of osteoarthritis.Conclusion ADAMTS-4 and-5 have been demonstrated to play important roles in osteoarthritis.It can better guide treatment and prevention of osteoarthritis to further study related mechanism of ADAMTS-4 and-5,and to promote the establishment of a clinical drug targets.

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Available abstract

Objective To review the progress of a disintegrin and metalloproteinase with thrombospondin motif 4(ADAMTS-4) and ADAMTS-5 in osteoarthritis.Methods Recent literature about the ADAMTS-4 and-5 in osteoarthritis was analyzed;the structure,function,inhibitors of the ADAMTS-4 and-5,and the relationship between the proteases and osteoarthritis were analyzed and summarized.Results ADAMTS-4 and-5 can reduce chondrocyte and extracellular matrix by degrading aggrecan and cartilage oligomeric matrix protein,which induced the pathogenesis of osteoarthritis.Conclusion ADAMTS-4 and-5 have been demonstrated to play important roles in osteoarthritis.It can better guide treatment and prevention of osteoarthritis to further study related mechanism of ADAMTS-4 and-5,and to promote the establishment of a clinical drug targets.

Key concepts: ADAMTS, Thrombospondin, Osteoarthritis, Disintegrin, Aggrecan, Medicine, Metalloproteinase, Extracellular matrix

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RESEARCH PROGRESS OF A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIF 4 AND 5 IN OSTEOARTHRITIS — Research Paper | ScholarLens