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2002•Journal of Experimental HematologyRequires access

Analysis of Serologic Typing Error for HLA-A and HLA-B in Chinese

Yu Dai

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Abstract

Serological mistypings of HLA A and HLA B in 27 cases were analyzed. The results showed that for HLA A and HLA B typing, the rates of incorrect antigen assignments were significantly higher than rates of antigen misses (P0.05), but there was no significant difference between HLA A and HLA B typings. The frequencies of miss assigned HLA A and HLA B specificities were A1(66.7%), A3(50.0%), A11(13.5%), A9(11.8%), A19(7.1%), and B16(50.0%), B48(43.9%), B15(16.7%), B40(11.1%), B13(10.0%) and B17(9.1%). In conclusion: the serologic and DNA based typing techniques should be reciprocally complementary in HLA A and HLA B typing.

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What this paper is about

Serological mistypings of HLA A and HLA B in 27 cases were analyzed. The results showed that for HLA A and HLA B typing, the rates of incorrect antigen assignments were significantly higher than rates of antigen misses (P0.05), but there was no significant difference between HLA A and HLA B typings. The frequencies of miss assigned HLA A and HLA B specificities were A1(66.7%), A3(50.0%), A11(13.5%), A9(11.8%), A19(7.1%), and B16(50.0%), B48(43.9%), B15(16.7%), B40(11.1%), B13(10.0%) and B17(9.1%). In conclusion: the serologic and DNA based typing techniques should be reciprocally complementary in HLA A and HLA B typing.

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Available abstract

Serological mistypings of HLA A and HLA B in 27 cases were analyzed. The results showed that for HLA A and HLA B typing, the rates of incorrect antigen assignments were significantly higher than rates of antigen misses (P0.05), but there was no significant difference between HLA A and HLA B typings. The frequencies of miss assigned HLA A and HLA B specificities were A1(66.7%), A3(50.0%), A11(13.5%), A9(11.8%), A19(7.1%), and B16(50.0%), B48(43.9%), B15(16.7%), B40(11.1%), B13(10.0%) and B17(9.1%). In conclusion: the serologic and DNA based typing techniques should be reciprocally complementary in HLA A and HLA B typing.

Key concepts: Typing, Serology, Human leukocyte antigen, HLA-A, HLA-B, Antigen, Immunology, Tissue typing

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