The effect of tamsulosin and dutasteride combination drug therapy on prostate volume in patients with benign prostatic hyperplasia

Abstract Benign prostatic hyperplasia (BPH) is a benign enlargement of the prostatic gland. This study was conducted to measure the improvement of prostate volume after treatment with Tamsulosin and Dutasteride as a combination drug in BPH patient at RSUD Kota Mataram from February 2020 to April 2020. The data were obtained by documenting the medical records of 20 new BPH patients ultrasound before and after 2 months therapy. This study was conducted using a comparative numerical analytical research model. The analysis was carried out by paired T-test in SPSS. A total of 20 medical records observed, the mean age of the study sample was 67.4 years, with the lowest age at 56 years and the oldest were 79 years, and 85% (17) of samples are more than 60 years old. The average prostate volume pre-therapy was 51.71 cc with the lowest volume was 25 cc and the highest volume 118 cc. Average prostate volume post-therapy was 42.38 cc, with the lowest volume was 22 cc and the highest 92 cc. The ratio of prostate volume more than 40 cc at pre-therapy was 50% (10 samples), and after therapy was decreased to 40% (8 samples). There are significant difference in comparison of pre and post-therapy prostate volume.