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Synthesis and Biodistribution of ~(131)I-BIB

Jiang Quanfu

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Abstract

The synthesis and biodistribution of 131I-1-iodo-2,5-bis(4'-amino)styrylbenzene(131I-BIB) were reported.The chemical structure of the labeling precursor 1-tributylstannyl-2,5-bis(4'-amino)styrylbenzene and all its intermediates were verified by IR,1H NMR and MS respectively.The radioiodinated compound was prepared using iododestannylation reaction by hydrogen peroxide.Labeling yield was more than 60% and radiochemical purity was more than 90% determined by thin layer chromatography(TLC).The in vivo biodistribution of 131I-BIB in ICR mice showed that the value of brain uptake was the highest in 30 min.

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What this paper is about

The synthesis and biodistribution of 131I-1-iodo-2,5-bis(4'-amino)styrylbenzene(131I-BIB) were reported.The chemical structure of the labeling precursor 1-tributylstannyl-2,5-bis(4'-amino)styrylbenzene and all its intermediates were verified by IR,1H NMR and MS respectively.The radioiodinated compound was prepared using iododestannylation reaction by hydrogen peroxide.Labeling yield was more than 60% and radiochemical purity was more than 90% determined by thin layer chromatography(TLC).The in vivo biodistribution of 131I-BIB in ICR mice showed that the value of brain uptake was the highest in 30 min.

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Available abstract

The synthesis and biodistribution of 131I-1-iodo-2,5-bis(4'-amino)styrylbenzene(131I-BIB) were reported.The chemical structure of the labeling precursor 1-tributylstannyl-2,5-bis(4'-amino)styrylbenzene and all its intermediates were verified by IR,1H NMR and MS respectively.The radioiodinated compound was prepared using iododestannylation reaction by hydrogen peroxide.Labeling yield was more than 60% and radiochemical purity was more than 90% determined by thin layer chromatography(TLC).The in vivo biodistribution of 131I-BIB in ICR mice showed that the value of brain uptake was the highest in 30 min.

Key concepts: Biodistribution, Chemistry, Hydrogen peroxide, Yield (engineering), Radiochemistry, Thin-layer chromatography, Specific activity, Nuclear chemistry

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