2010•Acta Scientiarum Naturalium Universitatis SunyatseniRequires access
Oncolytic adenovirus SG600-IL24 selectively kills hepatocellular carcinoma cell lines
Xinbo, Xue, Chao-Wen, Xiao Xiao, Hui, Zhang, Aiguo, Lü, Wei, Gao, Zhu-qing, Zhou, Xin-Lai, Guo, Ming-an, Zhong, YAO YAO, Yang, Cong-Jun, Wang
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Abstract
AIM: To investigate the effect of oncolytic adenovirus SG600-IL24 and replication-incompetent adenovirus Ad.IL-24 on hepatocellular carcinoma (HCC) cell lines and normal liver cell line. METHODS: HCC cell lines (HepG2, Hep3B and MHCC97L) and normal liver cell line (L02) with a different p53 status were infected with SG600-IL24 and Ad.IL-24, respectively. Melanoma differentiation-associated (MDA)-7/interleukin (IL)-24 mRNA and protein expressions in infected cells were detected by reverse transcription-polym...