Protein Acetylation in Prokaryotes

In addition to histones,recent evidences suggest many non-histone proteins are subject to lysine acetylation. Furthermore,lysine acetylation status has been shown to influence several fundamental cellular pathways,including cellular differentiation and metabolism. Protein lysine acetylation and its regulatory enzymes have thus emerged as a frontier for research in mammalian cells. Recent studies support that protein acetylation occurs prevalently in prokaryotes and broadly impacts prokaryotes physiology. An emerging theme from these studies is that metabolic enzymes involved in central metabolic pathways and intermediary metabolisms are subjected to acetylation. To explore more rapidly the impact of protein acetylation in bacteria,we will summarize the current examples of protein acetylation in prokaryotes,discuss the emerging link between acetylation and central metabolism and understand the importance of protein acetylation in bacteria.