The efficacy of parenteral nutrition with different energy for systemic inflammatory response syndrome(SIRS) in the aged

To evaluate the efficacy and safety of parenteral nutrition(PN) with lower or higher energy for treating systemic inflammatory response syndrome(SIRS) in the aged, thirty old SIRS critically ill patients were involved in a randomized control clinical trial. Fifteen cases were treated by PN with lower energy(105?KJ·kg -1 ·d -1 ), and another fifteen cases with higher energy(146?KJ·kg -1 ·d -1 ) for 6 days. The data about metabolisms of protein, glucose and fat, blood gas analysis, acute physiology and chronic heatlh evaluation(APACHE Ⅱ) were analysed. The results showed that: ① The effects of 105?KJ·kg -1 ·d -1 PN in increasing organism protein and maintaining nitrogen balance were the same as those of 146?KJ·kg -1 ·d -1 PN. ② The levels of fast blood sugar and triglyceride maintained unchanged in 105?KJ·kg -1 ·d -1 PN group, while they increased significantly in 146?KJ·kg -1 ·d -1 PN group(P0.05). ③ PaO 2 was raised greatly in 105?KJ·kg -1 ·d -1 PN group, while not in 146?KJ·kg -1 ·d -1 PN group. ④ 105?KJ·kg -1 ·d -1 PN and 146?KJ·kg -1 ·d -1 PN decreased APACHE Ⅱ(P0.05), but the efficiency of 105?KJ·kg -1 ·d -1 PN was better than that of 146?KJ·kg -1 ·d -1 PN(P0.05). We conclude that PN with 105?KJ·kg -1 ·d -1 energy intake is more effective and safer for treating SIRS than that with 146?KJ·kg -1 ·d -1 in the aged. [