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The dynamic changes in serologic HBV markers in infants born by HBsAg-carrying mothers

Cui Heng-chu

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Abstract

Objective To investigate the dynamic changes in hepatitis B virus serologic markers(HBVM) in infants born by HBsAg-carrying mothers,who were immunized with high-titer immunoglobulin(HTIG) and hepatitis B vaccine,and evaluate the clinical and epidemiological significance thereof.Methods Two hundred and nine HBsAg-carrying pregnant women and their 213 newborns(4 twins) were consecutively involved from Dec.2002 to Oct.2004,and followed up when infants were at 1,7,12,24 and 36 months of age.HBsAg,anti-HBs,HBeAg,anti-HBe and anti-HBc in neonatal sera were detected by ELISA.Results One hundred and eighty-two infants(85.45%) born of HBsAg-positive mothers were followed up.Of them 13 were HBsAg positive at birth.At the end of follow-up,all of them changed negative except two cases who were persistently positive for HBsAg.No one in 169 infants who were HBsAg-negative at birth changed to HBsAg-positive.About 57.69%(30/52) neonates born by both HBsAg and HBeAg positive mothers showed detectable levels of HBeAg.Similar to HBsAg,HBeAg was detectable in only 2 infants who were also HBsAg positive after 7 months of age,and all the other infants became HBeAg-negative.The anti-HBs positive rate of newborn infants of HBsAg-carrying mothers was 6.70%(12/179).After immunizing by HTIG and hepatitis B vaccine,the anti-HBs positive rate reached 82.46%(47/57) at 1 month of age and 91.77%(145/158) at 7 month of age.73.68%(28/38) of infants aged of 36 months showed detectable levels of anti-HBs.The anti-HBe positive rate of infants aged 1 month was 49.12%(28/57),and the anti-HBc positive rate was 100%(57/57).All infants became anti-HBe-negative at age of 24 months.The anti-HBc positive rate was still 84.81%(134/158) at 7 months of age and decreased to 21.05%(8/38) at 36 months of age.Conclusions The efficacy of HTIG combining with hepatitis B vaccine is fine in high risk infants born by HBsAg positive mothers.HBeAg,anti-HBe and anti-HBc can pass through human placenta from mother to fetus passively.

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Objective To investigate the dynamic changes in hepatitis B virus serologic markers(HBVM) in infants born by HBsAg-carrying mothers,who were immunized with high-titer immunoglobulin(HTIG) and hepatitis B vaccine,and evaluate the clinical and epidemiological significance thereof.Methods Two hundred and nine HBsAg-carrying pregnant women and their 213 newborns(4 twins) were consecutively involved from Dec.2002 to Oct.2004,and followed up when infants were at 1,7,12,24 and 36 months of age.HBsAg,anti-HBs,HBeAg,anti-HBe and anti-HBc in neonatal sera were detected by ELISA.Results One hundred and eighty-two infants(85.45%) born of HBsAg-positive mothers were followed up.Of them 13 were HBsAg positive at birth.At the end of follow-up,all of them changed negative except two cases who were persistently positive for HBsAg.No one in 169 infants who were HBsAg-negative at birth changed to HBsAg-positive.About 57.69%(30/52) neonates born by both HBsAg and HBeAg positive mothers showed detectable levels of HBeAg.Similar to HBsAg,HBeAg was detectable in only 2 infants who were also HBsAg positive after 7 months of age,and all the other infants became HBeAg-negative.The anti-HBs positive rate of newborn infants of HBsAg-carrying mothers was 6.70%(12/179).After immunizing by HTIG and hepatitis B vaccine,the anti-HBs positive rate reached 82.46%(47/57) at 1 month of age and 91.77%(145/158) at 7 month of age.73.68%(28/38) of infants aged of 36 months showed detectable levels of anti-HBs.The anti-HBe positive rate of infants aged 1 month was 49.12%(28/57),and the anti-HBc positive rate was 100%(57/57).All infants became anti-HBe-negative at age of 24 months.The anti-HBc positive rate was still 84.81%(134/158) at 7 months of age and decreased to 21.05%(8/38) at 36 months of age.Conclusions The efficacy of HTIG combining with hepatitis B vaccine is fine in high risk infants born by HBsAg positive mothers.HBeAg,anti-HBe and anti-HBc can pass through human placenta from mother to fetus passively.

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Available abstract

Objective To investigate the dynamic changes in hepatitis B virus serologic markers(HBVM) in infants born by HBsAg-carrying mothers,who were immunized with high-titer immunoglobulin(HTIG) and hepatitis B vaccine,and evaluate the clinical and epidemiological significance thereof.Methods Two hundred and nine HBsAg-carrying pregnant women and their 213 newborns(4 twins) were consecutively involved from Dec.2002 to Oct.2004,and followed up when infants were at 1,7,12,24 and 36 months of age.HBsAg,anti-HBs,HBeAg,anti-HBe and anti-HBc in neonatal sera were detected by ELISA.Results One hundred and eighty-two infants(85.45%) born of HBsAg-positive mothers were followed up.Of them 13 were HBsAg positive at birth.At the end of follow-up,all of them changed negative except two cases who were persistently positive for HBsAg.No one in 169 infants who were HBsAg-negative at birth changed to HBsAg-positive.About 57.69%(30/52) neonates born by both HBsAg and HBeAg positive mothers showed detectable levels of HBeAg.Similar to HBsAg,HBeAg was detectable in only 2 infants who were also HBsAg positive after 7 months of age,and all the other infants became HBeAg-negative.The anti-HBs positive rate of newborn infants of HBsAg-carrying mothers was 6.70%(12/179).After immunizing by HTIG and hepatitis B vaccine,the anti-HBs positive rate reached 82.46%(47/57) at 1 month of age and 91.77%(145/158) at 7 month of age.73.68%(28/38) of infants aged of 36 months showed detectable levels of anti-HBs.The anti-HBe positive rate of infants aged 1 month was 49.12%(28/57),and the anti-HBc positive rate was 100%(57/57).All infants became anti-HBe-negative at age of 24 months.The anti-HBc positive rate was still 84.81%(134/158) at 7 months of age and decreased to 21.05%(8/38) at 36 months of age.Conclusions The efficacy of HTIG combining with hepatitis B vaccine is fine in high risk infants born by HBsAg positive mothers.HBeAg,anti-HBe and anti-HBc can pass through human placenta from mother to fetus passively.

Key concepts: HBsAg, Medicine, HBeAg, Titer, Serology, Hepatitis B virus, Epidemiology, Hepatitis B

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The dynamic changes in serologic HBV markers in infants born by HBsAg-carrying mothers — Research Paper | ScholarLens