2013•中国神经再生研究：英文版Requires access
Electroacupuncture at He-Mu points reduces P2X4 receptor expression in visceral hypersensitivity
Xinxin, Guo, Ji-fei, Chen, Yuan, Lü, Luyi, Wu ., Zhijun, Weng, Ling, Yang Yang, Yuhu, Xin, Xianming, Lin, Yi Yi, Liang Liang, Jianqiao, Fang
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Abstract
Electroacupuncture at Shangjuxu (ST37) and Tianshu (ST25) was reported to improve visceral hypersensitivity in rats.Colorectal distension was utilized to generate a rat model of chronic visceral hypersensitivity in irritable bowel syndrome.Results showed that abdominal withdrawal reflex scores noticeably increased after model establishment.Simultaneously,P2X 4 receptor immunoreactivity significantly increased in the colon and spinal cord.Electroacupuncture and pinaverium bromide therapy both markedly decreased abdominal withdrawal reflex scores in rats with visceral hypersensitivity,and significantly decreased P2X 4 receptor immunoreactivity in the colon and spinal cord.These data suggest that electroacupuncture treatment can improve visceral hypersensitivity in rats with irritable bowel syndrome by diminishing P2X 4 receptor immunoreactivity in the colon and spinal cord.