Association of plasma levels of homocysteine,endothelin-1 and nitric oxide and hypertension with cerebral hemorrhage

Objective To investigate the relationship of plasma levels of homocysteine(Hcy),endothelin-1(ET-1) and nitric oxide(NO) and hypertension with cerebral hemorrhage.MethodsPlasma levels of Hcy,ET-1 and NO were examined in 62 patients with hypertension(group A),45 patients with cerebral hemorrhage without hypertension(group B),60 hypertensive patients with cerebral hemorrhage(group C) and 40 healthy volunteers(group D).Results For groups of A,B,C and D,plasma levels of Hcy were(17.6±6.6) μmol/L,(18.2±7.2) μmol/L,(21.9±6.7) μmol/L and(10.8±4.6) μmol/L,those of ET-1 were(100.7±11.8) μg/L,(101.2±12.1) μg/L,(120.8±15.9) μg/L and(44.7±10.6) μg/L,and those of NO were(57.2±11.7) mg/L,(58.6±11.2) mg/L,(41.8±13.2) mg/L and(120.8±12.6) mg/L,respectively.Compared with group D,plasma levels of Hcy and ET-1 were higher,but NO was lower in groups of A,B and C(P0.05).Plasma levels of Hcy and ET-1 were higher,but NO was lower in group C than those in groups of A and B(P0.05).The amount of cerebral hemorrhage was positively correlated to Hcy and ET-1,but negatively correlated with NO(P0.05).Conclusion The damage and dysfunction of the endothelial cells exist in the patients with hypertensive cerebral hemorrhage.